Animals are the main host of brucellosis, the main violation of the reproductive system of animals, can cause the abortion of mother animals and male animal infertility. Inter-animal transmission can be carried out by contact with aborted fetuses, uterine secretions, or drinking milk secreted by infected animals. Animals infected with brucellosis may be accompanied by severe clinical symptoms, or may be invisible infections that can be detoxified outwards over a long period of time. Whether it's a natural host, an experimental animal, or a human patient, brucellosis can manifest itself as a chronic process of consumption.
In marine mammals, brucellosis can affect animal reproduction performance leading to miscarriage, but also can cause meningoencephalitis, spleen, liver gangrene, etc. , more eventually lead to death. Brucelphine can be transmitted through respiratory and digestive mucosa inhuman and animal bodies, and between animals can also be transmitted through conjunctiva contact and mating. Bacteria enter the body and are swallowed by phagocytosis cells, reaching local lymph nodes, which then spread throughout the body. Brucelphine can effectively live in mononucleophic cells and macrophages and reproduce in large numbers in the liver and spleen. Brucellosis can also reproduce in animal breast tissue and reproductive organs, and any tissue organ in the body may have infected cells. A large number of propagated brucellosis can be found in host cells through histopathological observation. Current research on the intracellular sites of brucellosis in different stages of infection is not very thorough, but it can be clear that the replication sites of brucellosis in cells are directly related to their pathogenicity. The development of brucellosis in animals or humans as a chronic expendable disease is closely related to its survival time within the host cell and the host's immune response.